Background short stature and ovarian failure are characteristic features of turner's syndrome. Although recombinant human growth hormone is. To minimize the rate of side-effects, a retrospective analysis of 28 studies of gh replacement therapy in adults indicates that the maintenance dose should. Treatment of growth failure due to inadequate endogenous growth hormone secretion (genotropin, humatrope, norditropin, nutropin, nutropin aq,. As normal physiological growth hormone production decreases with age, dose requirements may be reduced. 3 treatment should stop when near adult height is. The recommended final growth hormone dose seldom exceeds 1. A daily dosage of 1 or 2 ius per injection. Injected in the late evening to mimic the body's natural growth hormone secretion cycle. Switching from daily human growth hormone (hgh; somatropin) therapy to once-weekly transcon hgh resulted in a similar safety and efficacy. Growth failure due to inadequate secretion of endogenous growth hormone (gh). Dose adjustments may be required annually, and will be based on changes in height and weight and igf 1 levels. Gh therapy is expensive and continuation has. Poor adherence and persistence can have a major negative impact on the long-term clinical effectiveness of recombinant human growth hormone (r-hgh) treatme. Alternate treatment strategies such as increased duration of gh treatment and high pubertal dosing of gh did not substantially improve the cost-effectiveness. Adults weighing more than 121 pounds (55 kg)—6 mg injected under the skin once a day at bedtime. Adults weighing 99 to 121 pounds (45 to 55 kg)
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